New, original images have been received from Ben Davidson (Oslo, Norway) about modern immunocytochemical markers that can be successfully applied to effusions. Some markers are clearly diagnostic (calretinin, MUC-4, HER2/neu...) whereas others may have a prognostic value. For example, the growth factor granulin-epithelin precursor (GEP) is a novel marker which may have predictive value for overall survival in epithelial ovarian cancer (Davidson et al, 2004).
Many thanks to Ben for those high quality images (to be completed at a later date by text and references).
Figures 1 and 2: HER2/neu in breast carcinoma (left), and GEP in ovarian carcinoma (right)
Figures 3 and 4: HLA-G in ovarian carcinoma (left), and MUC-4 in ovarian carcinoma (right)
Davidson B, Alejandro E, Florenes VA, Goderstad JM, Risberg B, Kristensen GB, Trope CG, Kohn EC. Granulin-epithelin precursor (GEP) is a novel prognostic marker in epithelial ovarien cancer. Cancer 2004, 100, 2139-2147