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31 mai 2011 2 31 /05 /mai /2011 10:57

The diagnostic and molecular characteristics of malignant mesothelioma and ovarian/peritoneal serous carcinoma

Ben Davidson (Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Norway) recently published in Cytopathology 2011 Feb;22(1):5-21

 

Malignant mesothelioma and ovarian/peritoneal serous carcinoma are two of the most common tumours affecting the serosal cavities. Unlike other malignant tumours diagnosed at this anatomical site, such as lung and breast carcinoma, malignant mesothelioma and serous carcinoma share a common histogenesis, may be difficult to differentiate morphologically, and co-express many of the diagnostic markers used by cytopathologists in effusion diagnosis.

 

Selected markers have nevertheless shown sufficient sensitivity and specificity to differentiate serous carcinoma from malignant mesothelioma effectively. Recently, our group applied high throughput technology to the identification of new markers that may aid in differentiating these two cancer types and validated several of these markers in follow-up studies. This review will present current data regarding the diagnostic and biological aspects of malignant mesothelioma and ovarian/peritoneal serous carcinoma.

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